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FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a γ-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the γ-Secretase Cleavage Complex

✍ Scribed by Weiming Xia; Beth L. Ostaszewski; W.Taylor Kimberly; Talat Rahmati; Chad L. Moore; Michael S. Wolfe; Dennis J. Selkoe

Book ID: 115641553
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 170 KB
Volume: 7
Category: Article
ISSN: 0969-9961
DOI: 10.1006/nbdi.2000.0322

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## Abstract The presenilin/γ‐secretase protease cleaves many type‐I membrane proteins, including the amyloid β‐protein (Aβ) precursor (APP). Previous studies have shown that apoptosis induces alterations in Aβ production in a caspase‐dependent manner. Here, we report that staurosporine (STS)‐induce