Role of potassium channels and nitric oxide in the effects of iloprost and prostaglandin E1 on hypoxic vasoconstriction in the isolated perfused lung of the rat
✍ Scribed by Monique Dumas; Jean-Paul Dumas; Luc Rochette; Charles Advenier; Jean-François Giudicelli
- Book ID
- 110002714
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 456 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0007-1188
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📜 SIMILAR VOLUMES
In the rat pulmonary vasculature perfused with blood in situ vasoconstriction induced by hypoxia was reversed by isoprenaline (doses greater than 1 ng) and adrenaline (doses greater than 30 ng) and exacerbated by phenylephrine but not UK 14304. Doses of adrenaline less than 30 ng had no effect, exce
## Abstract The endothelium relaxes vascular smooth muscle cells through at least three factors: nitric oxide (NO), prostacyclin (PGI~2~), and endothelium‐derived hyperpolarizing factor (EDHF). In the coronary circulation, we have conducted a series of experiments to study: 1) the inhibitory effect