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Role of poly(ADP-ribose) formation in DNA repair

✍ Scribed by Satoh, Masahiko S.; Lindahl, Tomas


Book ID
109780080
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
573 KB
Volume
356
Category
Article
ISSN
0028-0836

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## Abstract Concurrent activation of poly (ADP‐ribose) polymerase (PARP) and DNA ligase was observed in cultured human epidermal keratinocytes (HEK) exposed to the DNA alkylating compound sulfur mustard (SM), suggesting that DNA ligase activation could be due to its modification by PARP. Using HEK,