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Role of poly(ADP–ribose) polymerase (PARP) in DNA repair in sulfur mustard-exposed normal human epidermal keratinocytes (NHEK)

✍ Scribed by K. R. Bhat; B. J. Benton; D. S. Rosenthal; M. E. Smulson; R. Ray

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
121 KB
Volume
20
Category
Article
ISSN
0260-437X

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Poly (ADP-ribose) polymerase (PARP) is essential for sulfur mustard-induced DNA damage repair, but has no role in DNA ligase activation
✍ K. Ramachandra Bhat; Betty J. Benton; Radharaman Ray 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 121 KB

## Abstract Concurrent activation of poly (ADP‐ribose) polymerase (PARP) and DNA ligase was observed in cultured human epidermal keratinocytes (HEK) exposed to the DNA alkylating compound sulfur mustard (SM), suggesting that DNA ligase activation could be due to its modification by PARP. Using HEK,