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Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function

✍ Scribed by Hiroshi Kojima; Atsushi Shinagawa; Seiichi Shimizu; Hirotaka Kanada; Masaaki Hibi; Toshio Hirano; Toshiro Nagasawa

Book ID: 114216620
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 415 KB
Volume: 29
Category: Article
ISSN: 0301-472X
DOI: 10.1016/s0301-472x(01)00623-3

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Phosphatidylinositol 3-kinase (Pl-3K) plays a key role in several cellular processes, including mitogenesis, apoptosis, actin reorganization and vesicular trafficking. The molecular events involved in its activation have not been fully elucidated and several reports indicate that a key event for enz