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Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage

✍ Scribed by Eun Sil Kang; Im Sun Woo; Hyo Jung Kim; So Young Eun; Kyung Shin Paek; Hye Jung Kim; Ki Churl Chang; Jae Heun Lee; Hoon Taek Lee; Jin-Hoi Kim; Toru Nishinaka; Chihiro Yabe-Nishimura; Han Geuk Seo

Book ID: 113630341
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 1003 KB
Volume: 43
Category: Article
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2007.05.006

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re