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Role of p53 tumor suppressor gene product in human mammary epithelial cell immortalization

โœ Scribed by Vimla Band; Laurie Delmolino; Sorab Dalal; Elliot Androphy


Book ID
103723907
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
202 KB
Volume
24
Category
Article
ISSN
0360-3016

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In this study, we analyzed 10 human squamous cell carcinomas (SCCs) for alterations in the p53 tumor suppressor gene in exons 4 through 9 by single-strand conformation polymorphism (SSCP) analysis. We found that 2 of 10 SCCs displayed unusual SSCP alleles at exon 7 of the p53 gene. Subsequent clonin