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Role of p53 in cell cycle arrest induced by H. pylori

✍ Scribed by Ahmed, Amel; Smoot, Duane T.; Tackey, Robert; Walters, Curla S.; Allen, Cornell R.; Neapolitano, Matthew; Ashktorab, Hassan

Book ID
122782252
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
197 KB
Volume
118
Category
Article
ISSN
0016-5085

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Activation of the tumor suppressor protein p53 can lead to arrest in both G 1 and G 2 stages of the cell cycle and, in some cells, to apoptotic cell death. In this study, we showed that the p53 response to a chemotherapeutic drug, actinomycin D, was reversible in both normal and tumor cells, even wh