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Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

✍ Scribed by Brøsen, Kim; Zeugin, Tanja; Meyer, Urs A


Book ID
109845057
Publisher
Nature Publishing Group
Year
1991
Tongue
English
Weight
531 KB
Volume
49
Category
Article
ISSN
0009-9236

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Dextromethorphan (DXM) is commonly used as a probe for the metabolic activity of the debrisoquine isozyme (P-450 lID6) of the cytochrome P-450 mixed-function oxidase system. Several reports have described changes in P-450 activity with dietary alteration. This study was conducted to determine the ef