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Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease

✍ Scribed by Zhao, Lixia; Ma, Qiu-Lan; Calon, Frédéric; Harris-White, Marni E; Yang, Fusheng; Lim, Giselle P; Morihara, Takashi; Ubeda, Oliver J; Ambegaokar, Surendra; Hansen, James E

Book ID
109940763
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
864 KB
Volume
9
Category
Article
ISSN
1097-6256

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## Abstract A balance between cell survival and cell death is necessary for multicellular organisms to maintain homeostasis. The family of p21‐activated kinases (PAKs 1, 2, and 3) are Rho GTPase‐regulated serine/threonine kinases implicated in the regulation of a variety of cellular processes. The