O3-02-05: p21-activated kinase pathway defects and synaptic function in Alzheimer’s disease

Defective insulin signaling pathway and

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

✍ C.G. Jolivalt; C.A. Lee; K.K. Beiswenger; J.L. Smith; M. Orlov; M.A. Torrance; E 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 370 KB

## Abstract We have evaluated the effect of peripheral insulin deficiency on brain insulin pathway activity in a mouse model of type 1 diabetes, the parallels with Alzheimer's disease (AD), and the effect of treatment with insulin. Nine weeks of insulin‐deficient diabetes significantly impaired the