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Role of P-Glycoprotein in Ocular Clearance of Rhodamine 123 in Rabbits

โœ Scribed by Tetsu Kajikawa; Hiromu K. Mishima; Teruo Murakami; Mikihisa Takano

Book ID
110251981
Publisher
Springer US
Year
2000
Tongue
English
Weight
154 KB
Volume
17
Category
Article
ISSN
0724-8741

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Effect of interferons on P-glycoprotein-
Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes
โœ Yukiko Akazawa; Hiroko Kawaguchi; Maki Funahashi; Yoshihiko Watanabe; Kiyoshi Ya ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 139 KB

The effect of interferon (IFN)-beta and IFN-gamma on P-glycoprotein (P-gp)-mediated efflux of rhodamin-123(Rho-123), a typical substrate of P-gp, was studied in rat hepatocytes in primary culture. After treatment with IFN-beta, IFN-gamma, or both for 3 days, steady-state levels of Rho-123, incorpora