The effect of interferon (IFN)-beta and IFN-gamma on P-glycoprotein (P-gp)-mediated efflux of rhodamin-123(Rho-123), a typical substrate of P-gp, was studied in rat hepatocytes in primary culture. After treatment with IFN-beta, IFN-gamma, or both for 3 days, steady-state levels of Rho-123, incorpora
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Assessment of P-glycoprotein-dependent drug transport in isolated rat hepatocytes using rhodamine 123
โ Scribed by E. Chieli; E. Santoni Rugiu; F. Cervelli; A. Paolicchi; R. Tongiani
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 469 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0742-2091
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The hepatobiliary disposition of rhodamine 123 (RH-123) and its glucuronidated (RH-Glu) and deacylated (RH-110) metabolites were studied in an isolated perfused rat liver (IPRL) model in the presence and absence of P-glycoprotein (P-gp) and Mrp2 inhibitors. A single dose (180 mg) of RH-123 was added