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Role of oxygen radicals and IL-6 in IL-1-dependent cartilage matrix degradation

✍ Scribed by Masao Shingu; Tetsurou Isayama; Chie Yasutake; Takashi Naono; Masashi Nobunaga; Kazuhide Tomari; Katsuyuki Horie; Yukiko Goto


Publisher
Springer
Year
1994
Tongue
English
Weight
561 KB
Volume
18
Category
Article
ISSN
0360-3997

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✍ Vishwas Ganu; Ronald Goldberg; Jane Peppard; John Rediske; Richard Melton; Shou- πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 918 KB

Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti