## Abstract Neuronal apoptotic death involves the participation of reactive oxygen species (ROS), but their sources have not been completely elucidated. Previous studies have demonstrated that the ROS‐producing enzyme NADPH oxidase is present in neuronal cells and that this enzyme could participate
✦ LIBER ✦
Role of oxidative stress and JNK pathway in apoptotic death induced by potassium deprivation and staurosporine in cerebellar granule neurons
✍ Scribed by Yazmín Ramiro-Cortés; Julio Morán
- Book ID
- 116765331
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 847 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0197-0186
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When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300
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