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Role of nucleus basalis in cholinergic control of cortical blood flow

✍ Scribed by MD; PhD O. U. Scremin; C. Torres; A. M. E. Scremin; M. O'Neal; D. Heuser; K. S. Blisard's

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
848 KB
Volume
28
Category
Article
ISSN
0360-4012

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✦ Synopsis

The present investigation was designed to determine the effect of lesions localized to the nucleus basalisl substantia innominata (NB) on resting and cholinergically activated regional cerebral cortical blood flow (rCBF). Ibotenic acid (10 pg) was infused locally at 1 mm caudal to bregma, 3 mm lateral to the midline, and 8 mm below the cortical surface. Effectiveness of lesions was demonstrated by histological verification of lesion sites and determination of choline acetyltransferase activity in cerebral cortex homogenates. rCBF was measured with the autoradiographic iodo-14C-antipyrine technique. Resting rCBF was similar in the hemisphere that received the NB lesion and in the contralateral (intact) side in all regions examined. Physostigmine intravenous infusion (3.3 pg . kg-' * min-') enhanced rCBF in frontal, parietal, occipital, and temporal cortex. The increase was symmetrical, however, indicating inability of NB lesion to affect this phenomenon. It is concluded that the cortical cholinergic afferents originating in the NB are not involved in the control of rCBF.

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