Role of Nucleic Acid and Enzymes in Peptide Chain Synthesis
β Scribed by DOUNCE, ALEXANDER L.; MORRISON, MARTIN; MONTY, KENNETH J.
- Book ID
- 109586075
- Publisher
- Nature Publishing Group
- Year
- 1955
- Tongue
- English
- Weight
- 234 KB
- Volume
- 176
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/176597a0
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π SIMILAR VOLUMES
## Abstract Peptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or D
We synthesized flavin-containing PNA monomer unit 5 from lumiflavin and prepared PNAs containing a flavin moiety (FPNA) by the standard tBoc chemistry. Each PNA oligomer was purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses indicated that the PN