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Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease

✍ Scribed by Thierry Claudel; Gernot Zollner; Martin Wagner; Michael Trauner

Book ID
116270964
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
562 KB
Volume
1812
Category
Article
ISSN
0925-4439

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Abbreviations ## CDCA chenodeoxycholic acid Cyp7A cholesterol 7Ξ±-hydroxylase DCA deoxycholic acid FRET fluorescence resonance energy transfer FXR farnesoid X receptor LCA lithocholic acid LRH-1 liver receptor homologue-1 LXR liver X receptor RXR retinoid X receptor SF-1 steroidogenic factor-1

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## Abstract Chemical genomics is the name we have given to the analysis of gene function through use of small molecule chemical tools. Orphan nuclear receptors are ideally suited to this technique of functional analysis, since their activity as transcription factors is regulated by small hydrophobi