## Abstract Chemical genomics is the name we have given to the analysis of gene function through use of small molecule chemical tools. Orphan nuclear receptors are ideally suited to this technique of functional analysis, since their activity as transcription factors is regulated by small hydrophobi
Nuclear receptor regulation of cholesterol and bile acid metabolism
β Scribed by Joyce J Repa; David J Mangelsdorf
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 149 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0958-1669
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β¦ Synopsis
Abbreviations
CDCA chenodeoxycholic acid
Cyp7A cholesterol 7Ξ±-hydroxylase DCA deoxycholic acid FRET fluorescence resonance energy transfer FXR farnesoid X receptor LCA lithocholic acid LRH-1 liver receptor homologue-1 LXR liver X receptor RXR retinoid X receptor SF-1 steroidogenic factor-1
π SIMILAR VOLUMES
Bile acid synthesis is believed to be regulated by bile salts returning to the liver via the portal vein and suppressing cholesterol 7a-hydroxylase, the rate-limiting enzyme in the bile acid biosynthesis pathway. In order to characterize the relative effectiveness of bile salts in regulating bile ac
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