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Role of NQO1 polymorphisms as risk factors for squamous cell carcinoma of the head and neck

✍ Scribed by Asher Begleiter; Alia Norman; Darren Leitao; Teresa Cabral; Donna Hewitt; Sushu Pan; Jennifer R. Grandis; Jill M. Siegfried; Samy El-Sayed; Donna Sutherland; David A. Ross; Paul D. Kerr


Book ID
113832581
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
112 KB
Volume
41
Category
Article
ISSN
1368-8375

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Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN). Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing genes glutathione-S-transferase (GST) T1 and