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Role of nitric oxide in radiation-induced initiation of mammary tumorigenesis in rats

✍ Scribed by Hiroshi Inano; Makoto Onoda

Book ID
117730906
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
138 KB
Volume
8
Category
Article
ISSN
1089-8603

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## Abstract Nitric oxide (NO), an important regulatory molecule for immune response and cytotoxicity, is endogenously generated from l‐arginine by NO synthase (NOS). One mechanism for NO‐induced cytotoxicity is through its interaction with superoxide to produce peroxynitrite, which causes DNA damag