## Abstract Studies suggest that cholesterol imbalance in the brain might be related to the development of neurological disorders. U18666A is a well‐known amphiphile which inhibits intracellular cholesterol transport in treated cells. We have previously shown that U18666A leads to apoptosis and cho
Role of neuronal glutamate transporter in the cysteine uptake and intracellular glutathione levels in cultured cortical neurons
✍ Scribed by T. Himi; M. Ikeda; T. Yasuhara; M. Nishida; I. Morita
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 393 KB
- Volume
- 110
- Category
- Article
- ISSN
- 1435-1463
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Glutamate‐induced excitotoxicity has been implicated as an important mechanism underlying a variety of brain injuries and neurodegenerative diseases. Previously we have shown that taurine has protective effects against glutamate‐induced neuronal injury in cultured neurons. Here we propo
## Abstract The presence of glia and glial glutamate transporters seems to modify glutamate‐mediated toxicity in neuronal cultures. In this work we cultured cortical cells in serum‐containing medium and in a serum‐free medium (Neurobasal medium + B27 supplement) and studied the expression of the gl
The extracellular glutamate concentration is kept low by glutamate transporters in the plasma membranes. Here we have studied the expression of the glutamate transporters GLAST, GLT and EAAC during the in vitro development of embryonic hippocampal neurons grown in a defined (serum free) medium. Immu
## Abstract Maintenance of appropriate intracellular glutathione (GSH) levels is crucial for cellular defense against oxidative damage. A suggested mechanism of methylmercury (MeHg) neurotoxicity implicates the involvement of oxygen radical formation and a decrease in cellular levels of GSH. Astroc