Role of multiplex FISH in identifying chromosome involvement in myelodysplastic syndromes and acute myeloid leukemias with complex karyotypes: a report on 28 cases
✍ Scribed by Emmanuelle Barouk-Simonet; Valérie Soenen-Cornu; Christophe Roumier; Alain Cosson; Jean-Luc Laï; Pierre Fenaux; Claude Preudhomme
- Book ID
- 113512538
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 454 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0165-4608
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Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi
## Abstract Patients with acute myeloid leukemia (AML) and a complex aberrant karyotype have a poor outcome despite intensive antileukemic treatment. The aim of this study was to analyze in detail the genetic abnormalities in this subgroup of AML. Therefore, 125 AML cases with complex aberrant kary