## Role of LFA-l/ICAM-1 in interleukin-2-stimulated lymphocyte proliferation Major adhesion routes between lymphoid cells involve the receptorAigand pairs LFA-l/ICAM-1 and CD2/LFA-3, in addition toVLA or CD44 molecules. In this study we evaluated the role of these adhesion receptors in the prolife
Role of ligands in the activation of LFA-1
β Scribed by Christopher D. Buckley; Elaine D. Ferguson; Amanda J. Littler; David Bossy; David L. Simmons
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 557 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0014-2980
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The functional role of the LFA-1 molecule in the interaction between helper T lymphocytes and B lymphocytes was investigated using lymphocytes from patients with leukocyte adhesion deficiency, an inherited immunodeficiency characterized by a defective leukocyte expression of the LFA-1, Mac-1 (CR3) a
Interleukin 1 (IL I), but not IL 2-induced thymocyte proliferation was augmented by monoclonal antibodies (mAb) against the Ly 1 antigen. The anti-Ly 1 mAb could also co-stimulate thymocytes with phytohemagglutinin (PHA) alone, mimicking the effect of IL1. Moreover, overnight culture with PHA of thy