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Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene

✍ Scribed by Chen, Xin-Sheng; Shelter, James R.; Johnson, Eric N.; Funk, Colin D.


Book ID
109790288
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
475 KB
Volume
372
Category
Article
ISSN
0028-0836

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## Abstract Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5‐lipoxygenase pathway. Current models of this enzymatic pathway recognize that a key step in initiating leukotriene synthesis is the calcium‐media