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Role of intra-arterial steroid administration in the management of steroid-refractory acute gastrointestinal graft-versus-host disease

✍ Scribed by Arafat Tfayli; George Selby; Feroz Maqbool; Walter Bierbaum; Mehdi Hamadani

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 253 KB
Volume: 81
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.20711

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✦ Synopsis

Abstract

We report here a case of severe steroid‐refractory gastrointestinal graft‐versus‐host disease treated with intra‐arterial administration of corticosteroids. A 53‐year‐old female with non‐Hodgkin's lymphoma received peripheral blood hematopoietic stem cell transplant from her HLA‐matched sibling. She developed grade II skin and grade IV gastrointestinal graft‐versus‐host disease with no hepatic involvement. Therapy with oral prednisone easily controlled her skin rash but she had profuse diarrhea that did not respond to high dose intravenous corticosteroids and denileukin diftitox. Infusion of methyl‐prednisolone into superior and inferior mesenteric arteries produced dramatic improvement of diarrhea, with complete resolution of gastrointestinal graft‐versus‐host disease. Am. J. Hematol., 2006, © 2006 Wiley‐Liss, Inc.

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✍ Sato, Tsutomu; Sakamaki, Sumio; Nagaoka, Yasuhiro; Kuribayashi, Kageaki; Nagamac 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 1 views

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