Intra-mesenteric artery steroid administration relieved severe refractory gastro-intestinal graft-vs.-host disease in an allogeneic bone marrow transplantation patient
✍ Scribed by Sato, Tsutomu; Sakamaki, Sumio; Nagaoka, Yasuhiro; Kuribayashi, Kageaki; Nagamachi, Yasuhiro; Morii, Kazuhiro; Honma, Hisato; Kogawa, Katsuhisa; Kato, Junji; Niitsu, Yoshiro
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 159 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
We report a case of severe gastro-intestinal (G-I) graft-vs.-host disease (GVHD) successfully treated with intra-mesenteric artery steroid administration. A 29-year-old man with severe aplastic anemia (SAA) was submitted to HLA-identical unrelated allogeneic bone marrow transplantation (BMT) and was found to be suffering from grade IV G-I GVHD. Although cyclosporine, steroid pulse therapy, and FK506 proved ineffective, 30 mg of water-soluble prednisolone as administered into each the superior and inferior mesenteric artery with remarkable effects. This treatment was repeated two times, and the symptoms of G-I GVHD disappeared completely.