Role of inflammation in chemical-induced hepatotoxicity
โ Scribed by Michael I. Luster; Petia P. Simeonova; Randle M. Gallucci; Alex Bruccoleri; Mark E. Blazka; Berran Yucesoy
- Book ID
- 119536990
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 149 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0378-4274
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Hepatotoxicity induced by various therapeutic agents, industrial chemicals and environmental polIutants is a well-recognized phenomenon. These chemicals are known to cause liver damage that is localized to either periportal or centrilobular regions of the liver lobule (1-3). Depending on dose, durat
Research into the pathogenesis of acetaminophen (paracetamo1)-induced hepatotoxicity has concentrated on the generation of toxic metabolites by the hepatocytes. It has, however, recently been shown that human macrophages cultured with acetaminophen secrete increased quantities of tumour necrosis fac