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Controversial role of intracellular iron in the mechanisms of chemically-induced hepatotoxicity

✍ Scribed by Badr, Mostafa Z.

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
498 KB
Volume
9
Category
Article
ISSN
0887-2082

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✦ Synopsis

Hepatotoxicity induced by various therapeutic agents, industrial chemicals and environmental polIutants is a well-recognized phenomenon. These chemicals are known to cause liver damage that is localized to either periportal or centrilobular regions of the liver lobule (1-3). Depending on dose, duration, and route of exposure, the resultant liver injury may regress or progress and becomes irreversible (1). Mechanisms involved in this selective, localized toxicity have been the target of extensive research efforts, and many studies produced conflicting results. As depicted in Figure 1, although many investigators implicate iron and lipid peroxidation in this process (4-9), others dispute such assertions (10-12).

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