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Role of ICAM-1 and P-selectin expression in the development and effector function of CD4+CD25+regulatory T cells

✍ Scribed by Adam P. Kohm; Stephen D. Miller


Book ID
117609233
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
363 KB
Volume
21
Category
Article
ISSN
0896-8411

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## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut