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Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance

✍ Scribed by Kilic, M; Kasperczyk, H; Fulda, S; Debatin, K-M

Book ID
110072014
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
315 KB
Volume
26
Category
Article
ISSN
0950-9232

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## Abstract ## BACKGROUND Hypoxia occurs in association with cancer development, the result being a more aggressive and metastatic cancer phenotype. Hypoxia, which activates hypoxia‐inducible factor‐1 alpha (HIF‐1Ξ±), is associated with a number of cellular changes including increased apoptotic res