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Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals

✍ Scribed by Olivier Duverger; Maria I. Morasso

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
463 KB
Volume
216
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Homeobox genes are an evolutionarily conserved class of transcription factors that are key regulators during developmental processes such as regional specification, patterning, and differentiation. In this review, we summarize the expression pattern, loss‐ and/or gain‐of‐function mouse models, and naturally occurring mouse and human mutations of known homeobox genes required for the development of ectodermal appendages. J. Cell. Physiol. 216: 337–346, 2008. Β© 2008 Wiley‐Liss, Inc.

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