Role of H-2 antigens in the host response to methylcholanthrene-induced tumors
✍ Scribed by Lars Ährlund-Richter; Eva Klein; Fernando Merino
- Publisher
- Springer-Verlag
- Year
- 1982
- Tongue
- English
- Weight
- 526 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0093-7711
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## Abstract The tumor‐associated transplantation antigen (TATA), alien H‐2^k^ antigens and normal H‐2^d^ antigens expressed on a methylcholanthrene‐induced tumor were monitored during gel filtration and lectin affinity chromatography of detergent‐solubilized tumor‐cell membranes. TATA was resolved
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## Abstract Immune resistance to methylcholanthrene‐induced tumors has two phases, an early specific and a late non‐specific phase. Both phases were found to be T‐cell‐dependent in vivo. Thus, adult thymectomized, irradiated, bone‐marrow‐protected mice bearing H‐1 tumor isografts showed impaired re