✦ LIBER ✦

Role of gene regulation in song circuit development and song learning

✍ Scribed by Clayton, David F.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 225 KB
Volume: 33
Category: Article
ISSN: 0022-3034
DOI: 10.1002/(sici)1097-4695(19971105)33:5<549::aid-neu5>3.0.co;2-4

No coin nor oath required. For personal study only.

✦ Synopsis

The songbird has emerged as an imsinging and listening cause dramatic increases in gene portant model for study of brain-behavior relationexpression in brain areas specific to each activity. The ships by virtue of its rich natural advantages and from sensitivity of gene activation is modulated as a result the pioneering efforts of explorers using anatomical of experience in adulthood and also changes during and behavioral approaches. Now, molecular biology juvenile song learning. These studies have provided is providing a new and complementary paradigm for unexpected insights into the functional organization discerning songbird brain organization and function. of the song circuit and the potential role of extrinsic Here, I review the work over the last 10 years that has modulatory systems in directing and limiting plastic laid the foundation for approaching songbird biology change in the brain. With this rich base of knowledge, from the molecular perspective. As a result of this and techniques of gene manipulation on the horizon, work, specific hypotheses can now be framed and answers to old questions seem within our reach: What tested regarding the mechanisms behind song circuit sets the boundaries of neural plasticity? What limits formation, behavioral plasticity, and the boundaries learning? ᭧ 1997 John Wiley & Sons, Inc. J Neurobiol 33: 549- of adaptability. Age-related changes in more than 15 571, 1997 molecules have been observed in the song system of

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