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Role of extracellular cGMP and of hyperammonemia in the impairment of learning in rats with chronic hepatic failure: Therapeutic implications

✍ Scribed by Slaven Erceg; Pilar Monfort; Omar Cauli; Carmina Montoliu; Marta Llansola; Blanca Piedrafita; Vicente Felipo


Book ID
116764747
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
110 KB
Volume
48
Category
Article
ISSN
0197-0186

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## Abstract Brain edema in acute hepatic encephalopathy (HE) is due mainly to swelling of astrocytes. Efflux of potassium is implicated in the prevention of glial swelling under hypoosmotic conditions. We investigated whether pathogenic factors of HE, glutamine (Gln) and/or ammonia, induce alterati