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Role of endogenous free iron in activation of lipid peroxidation during ischemia

✍ Scribed by A. V. Kozlov; L. I. Shinkarenko; Yu. A. Vladimirov; O. A. Azizova


Publisher
Springer US
Year
1985
Tongue
English
Weight
394 KB
Volume
99
Category
Article
ISSN
0007-4888

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The role of iron in the initiation of li
✍ Giorgio Minotti; Steven D. Aust πŸ“‚ Article πŸ“… 1987 πŸ› Elsevier Science 🌐 English βš– 952 KB

Iron is required for the initiation of lipid peroxidation. Evidence is presented that lipid peroxidation requires both Fe 3Γ· and Fe aΓ·, perhaps with oxygen to form a Fe3+-dioxygen-Fe 2Γ· complex. Other mechanisms of initiation, mostly involving the iron-catalyzed formation of hydroxyl radical, axe de