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Role of cytochrome P4501A1 in biotransformation of a tissue specific sarcomagen N-methyldibenzo[c,g]carbazole

✍ Scribed by Alena Gábelová; Gabriela Bačová; L’ubica Ružeková; Timea Farkašová

Book ID
117766597
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
303 KB
Volume
469
Category
Article
ISSN
1383-5718

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✍ Danièle Taras-Valéro; Odette Périn-Roussel; Marie-José Plessis; François Zajdela 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 152 KB 👁 2 views

The potent multitissue carcinogen 7H-dibenzo-[c,g]carbazole and nine methylated derivatives, synthesized on the basis of the positions in the parent compound that are involved in metabolism, were tested for their ability to induce sarcomas and hepatic tumors in XVIInc/Z mice. In addition, the capaci