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Role of Cytochrome P4501 Family Members in the Metabolic Activation of Polycyclic Aromatic Hydrocarbons in Mouse Epidermis

โœ Scribed by Kleiner, Heather E.; Vulimiri, Suryanarayana V.; Hatten, William B.; Reed, Melissa J.; Nebert, Daniel W.; Jefcoate, Colin R.; DiGiovanni, John


Book ID
118149914
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
143 KB
Volume
17
Category
Article
ISSN
0893-228X

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## Abstract The polycyclic aromatic hydrocarbons (PAHs) phenanthrene and retene (7โ€isopropylโ€1โ€methyl phenanthrene) are lethal to rainbow trout __(Oncorhynchus mykiss)__ larvae during chronic exposures. Phenanthrene is a lowโ€toxicity, nonโ€cytochrome P4501A (CYP1A)โ€”inducing compound that accumulates