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Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

✍ Scribed by Hu, Y.


Book ID
111746042
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
290 KB
Volume
18
Category
Article
ISSN
0261-4189

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Cytochrome c and dATP-Dependent Formatio
✍ Peng Li; Deepak Nijhawan; Imawati Budihardjo; Srinivasa M Srinivasula; Manzoor A πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 804 KB

We report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3 was identified as a member of the caspase family, caspase-9. Caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the prese