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Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

โœ Scribed by Peng Li; Deepak Nijhawan; Imawati Budihardjo; Srinivasa M Srinivasula; Manzoor Ahmad; Emad S Alnemri; Xiaodong Wang


Book ID
117267384
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
804 KB
Volume
91
Category
Article
ISSN
0092-8674

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Cytochrome c and dATP-Dependent Formatio
โœ Peng Li; Deepak Nijhawan; Imawati Budihardjo; Srinivasa M Srinivasula; Manzoor A ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 804 KB

We report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3 was identified as a member of the caspase family, caspase-9. Caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the prese