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Role of Cys111 in an oxidative damage of human Cu/Zn-superoxide dismutase

✍ Scribed by Noriko Fujiwara; Miyako Nakano; Daisaku Yoshihara; Tomomi Ookawara; Hironobu Eguchi; Naoyuki Taniguchi; Keiichiro Suzuki

Book ID: 116775302
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 101 KB
Volume: 58
Category: Article
ISSN: 0168-0102
DOI: 10.1016/j.neures.2007.06.1268

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## Abstract We have expressed and characterized a mutant of __Xenopus laevis__ Cu, Zn superoxide dismutase in which four highly conserved charged residues belonging to the electrostatic loop have been replaced by neutral side chains: Lys120 → Leu, Asp130 → Gln, Glu131 → Gln, and Lys134 → Thr. At lo