## Abstract ## BACKGROUND. In estrogen biosynthetic pathways, many enzymes are important for metabolism, detoxification, and bioavailability. Polymorphisms in these genes may have an effect on the enzymes' function. For example, higher expression and activation of biosynthetic enzymes and lower ex
β¦ LIBER β¦
Role of CYP17 and SULT1A1 gene polymorphisms in breast cancer
β Scribed by B Rajan; P Chacko; M Pillai
- Book ID
- 118622115
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 185 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1359-6349
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## Abstract Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the __SULT1A1 his__ (__histidine__) allele, which is caused by a __his__ for __arg__ (__arginine__) substitution due to a GβA transition at codon 213,