## Role of TGF-β€ in Oncogenesis Transforming growth factor-β€ (TGF-β€) is the founding member of a large and growing family of growth factors with regulatory properties of a multitude of cellular processes including cell proliferation, differentiation, motility, adhesion, and death. Given this multi
Role of cyclophilin a during oncogenesis
β Scribed by Jinhwa Lee
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 162 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0253-6269
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## Abstract Activating Transcription Factorβ2 is a sequenceβspecific DNAβbinding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including __cyclin A, cyclin D__ and __cβjun__,
## Abstract Cyclophilin D (Cyp D) is implicated in cell death pathway and blockade of Cyp D could be a potent therapeutic strategy for degenerative disorders such as Alzheimer's disease, ischemia, and multiple sclerosis, but physiological role of Cyp D remains elusive. Here, we investigated the abi