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Role of concentration-dependent plasma protein binding in disopyramide disposition

✍ Scribed by Peter J. Meffin; Edward W. Robert; Roger A. Winkle; Sandra Harapat; Flora A. Peters; Donald C. Harrison

Book ID
112472394
Publisher
Springer
Year
1979
Tongue
English
Weight
996 KB
Volume
7
Category
Article
ISSN
1573-8744

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✍ David B. Haughey; John J. Lima πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 494 KB πŸ‘ 1 views

## Abstract Concentrations of disopyramide (D) and mono‐N‐dealkyldisopyramide (MND) were measured in serum and urine following administration of 100, 150, 200, and 300 mg D to four volunteers. The free fraction of D in serum was drug concentration‐dependent in all four subjects following the admini