✦ LIBER ✦

Dose-Dependent protein binding and disposition of prednisolone in rabbits

✍ Scribed by Mario L. Rocci Jr.; William J. Jusko

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 395 KB
Volume: 70
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600701105

No coin nor oath required. For personal study only.

✦ Synopsis

Mean minimum quantifiable level (MQL) was 0.01 K g / g . * No sample.

📜 SIMILAR VOLUMES

The nonlinear pharmacokinetics of predni

The nonlinear pharmacokinetics of prednisone and prednisolone. II. Plasma protein binding of prednisone and prednisolone in rabbit and human plasma

✍ Jame S. J. Ferry; John G. Wagner 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 451 KB 👁 2 views

The protein binding characteristics of prednisone and prednisolone were determined in human and rabbit plasma and in a 4.7 per cent human serum albumin (HSA) solution. The influence of plednisolone on prednisone binding in human plasma was also examined. Prednisolone exhibited nonlinear binding and

Serum protein binding of prednisolone in

Serum protein binding of prednisolone in four species

✍ Mario L. Rocci Jr.; Noreen F. Johnson; William J. Jusko 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB

Dose-dependent disposition of oral propr

Dose-dependent disposition of oral propranolol in normal subjects

✍ Janis J. Mackichan; Dennis R. Pyszczynski; William J. Jusko 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 376 KB

## Abstract The pharmacokinetics and relative systemic availability or oral propranolol were studied in three healthy volunteers following administration of 10, 40, and 80 mg of propranolol hydrochloride. Plasma concentrations of propranolol were determined using a sensitive and specific fluorometr

Blood collection technique: No effect on

Blood collection technique: No effect on in vitro protein binding of prednisolone

✍ Mario L. Rocci Jr.; William J. Jusko 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB 👁 1 views

DOSE-DEPENDENT DISTRIBUTION VOLUMES OF T

DOSE-DEPENDENT DISTRIBUTION VOLUMES OF TOTAL AND UNBOUND VALPROATE IN GUINEA-PIGS: CONSEQUENCE OF NON-LINEAR PLASMA PROTEIN BINDING

✍ Hsui-Ying Yu; Yu-Zen Shen 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 475 KB 👁 2 views

The response of steady-state distribution volume (V,, for total and Vdssu for unbound drug) of valproate (VPA) to dose-dependent plasma protein binding was studied in guinea-pigs. Various steady-state plasma concentrations of VPA were achieved by intravenous constant infusion. The concentrations of

Plasma protein binding of celecoxib in m

Plasma protein binding of celecoxib in mice, rat, rabbit, dog and human

✍ Susan K. Paulson; Todd A. Kaprak; Christopher J. Gresk; Douglas M. Fast; Mike T. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 2 views

The plasma protein binding of celecoxib was determined for animals and humans using in vitro and ex vivo methods. Eight, healthy, human volunteers (three male, five female, 20-39 years) received celecoxib (600 mg) BID for 7 days, blood samples were collected and concentrations of bound and unbound c