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Role of cDNA-Expressed Human Cytochromes P450 in the Metabolism of Diazepam

✍ Scribed by Tian J Yang; Magang Shou; Kenneth R Korzekwa; Frank J Gonzalez; Harry V Gelboin; Shen K Yang

Book ID
119407493
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
432 KB
Volume
55
Category
Article
ISSN
0006-2952

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## Objectives: The biotransformation of caffeine has been studied in vitro using human cytochrome p-450 isoenzymes (cyps) expressed in human b-lymphoblastoid cell lines, namely cyp1a1, 1a2, 2a6, 2b6, 2d6-val, 2e1 and 3a4, and microsomal epoxide hydroxylase (eh). in addition, cyp2d6-met was also stu