Role of CD44 cytoplasmic domain in hyaluronan binding
β Scribed by Astrid Perschl; Jayne Lesley; Nicole English; Ian Trowbridge; Robert Hyman
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 847 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0014-2980
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We previously found that monoclonal antibodies (MAbs) directed against the constant region of the CD44 molecule block lymph node infiltration of a mouse LB T-cell lymphoma, suggesting a role for this glycoprotein in the LB cell dissemination process. In the present study, we investigated whether LB
## Abstract ## Objective To determine whether aggrecan fragments bound to hyaluronan (HA) can be retained and internalized by articular chondrocytes and whether these events are dependent on HA and its receptor, CD44. An additional objective was to determine whether partial degradation of aggrecan