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Role of CD137 (4-1BB) in the SCID T cell transfer colitis model

✍ Scribed by Maerten, Philippe; Shen, Chong; Cadot, Pascal; Van assche, Gert; Geboes, Karel; Kwon, Byoung; Rutgeerts, Paul; Ceupens, Jan

Book ID: 123571083
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 174 KB
Volume: 124
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(03)81678-5

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## Abstract The initial requirement for the emergence of CMV‐specific CD8^+^ T cells is poorly understood. Mice deficient in the cosignaling TNF superfamily member, 4‐1BB, surprisingly developed exaggerated early CD8^+^ T‐cell responses to mouse CMV (MCMV). CD8^+^ T cells directed against acute MCM