Acetaminophen is a mild analgesic and antipyretic agent known to cause centrilobular hepatic necrosis at toxic doses. Although this may be due to a direct interaction of reactive acetaminophen metabolites with hepatocyte proteins, recent studies have suggested that cytotoxic mediators produced by pa
Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse
β Scribed by Donna M. Dambach; Linda M. Watson; Kevin R. Gray; Stephen K. Durham; Debra L. Laskin
- Book ID
- 111721844
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 437 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0270-9139
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## Abstract Neutrophils and macrophages infiltrate after acetaminophen (APAP)βinduced liver injury starts to develop. However, their precise roles still remain elusive. In untreated and control IgGβtreated wildβtype (WT) mice, intraperitoneal APAP administration (750βmg/kg) caused liver injury incl
The effect of prostacyclin on acetaminophen-induced liver injury has been investigated in the mouse. Two structurally unrelated thromboxane synthetase inhibitors, OKY 1581 and benzyl imidazole, were also examined in order to investigate the role of the prostacyclinthromboxane balance in the developm