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Role of bile in pathogenesis of indomethacin-induced enteropathy

✍ Scribed by Molly Jacob; Russel Foster; Gudmundur Sigthorsson; Robert Simpson; Ingvar Bjarnason

Publisher: Springer-Verlag
Year: 2006
Tongue: English
Weight: 346 KB
Volume: 81
Category: Article
ISSN: 0340-5761
DOI: 10.1007/s00204-006-0149-2

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## Abstract Gastric mucosal ulceration was produced in rats following intraperitoneal injection of indomethacin (40 mg/kg). The incidence of ulcerations was progressively reduced as the bile flow was diverted progressively distal to the ampulla of Vater. It is suggested that bile reflux into the st